![]() regulated define In a basket trial that included patients with a variety of cancers, all of which contained a BRAF V600 mutation, the rate of response to vemurafenib was highly variable. Basket trials offer a cost-effective option to evaluate targeted agents in multiple malignancies, but it is important to be aware of their limitations. ![]() A total of 122 patients with BRAF V600 mutation–positive. Methods We enrolled patients in six prespecified cancer cohorts patients with all other tumor types were enrolled in a seventh cohort. Basket trials are phase II screening trials for the off-label use of a targeted drug in patients with the same genomic alterations for which it was approved. ![]()
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